The Ross Laboratory is happy to bring C. briggsae expertise to California State University, Fresno, a Masters-level public university located not far from where Margaret Briggs initially isolated C. briggsae. Research by undergraduate and Masters students in my laboratory (lab code FV: Fresno Variant) pertains to the genetic basis of species formation. Building on discoveries I made while improving the C. briggsae genome assembly as a post-doc in Eric Haag’s lab at University of Maryland, College Park (Ross et al., 2011), our current efforts are focused on identifying the genetic architecture and evolutionary history of an apparent mitochondrial-nuclear genetic incompatibility between two strains of C. briggsae. Current experimental approaches comprise classical genetic techniques coupled with confocal microscopy and genomics.
Ross J, Koboldt D, Staisch J, Chamberlin H, Gupta B, Miller R, Baird S, Haag E. (2011) Caenorhabditis briggsae recombinant inbred line genotypes reveal inter-strain incompatibility and the evolution of recombination. PLoS Genetics 7, e1002174.
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