Worm Breeder's Gazette 9(1): 40
These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.
Our analysis of LGV(left) is continuing. At present 10 deletions, providing 13 different breakpoints, divide the region into 14 zones ( figure). The table shows recessive lethal mutations that have been mapped to the zones. [See Figure 1] At Cold Spring Harbor (1985) we noted that deletion mapping placed unc-34 to the left of unc-60. This has been additionally confirmed by 3-factor mapping. The two genes are 0.8 - 3.4 m.u. apart. Another gene, let-336 has now been deletion-mapped to the left of unc-34 and therefore becomes the current left-end gene of LGV. One of us (Kim McKim) has begun an intragenic mapping study of unc- 60. We are in possession of the alleles, e677, e723, e890 and m35 and would greatly appreciate receiving others. We have noticed that at least e677 and m-35 differ greatly regarding their viability as heterozygotes over sDf28: e677/sDf28 barely survives while m35/sDf28 survives well. This relationship correlates with their respective homozygous phenotypes, - m35 being more mobile than e677.