Worm Breeder's Gazette 7(2): 39

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Cell Proliferation in lin-23 Mutants

E. Hedgecock

Figure 1

A recessive mutation e1883 (lin-23) on linkage group II causes extra
cell divisions in probably all postembryonic lineages, including an
extra round of strictly nuclear division in the intestine. In the
hypodermis, the number and timing of the extra divisions vary but,
generally, these are of the form [See Figure 1] except in the L2 when
the number of seam cells increases in both mutants and wild types.
All four descendents of M.dl/r undergo additional divisions but
apparently only one coelomocyte is produced, the other cells being
muscles. This suggests that the commitment to becoming a coelomyocyte
is segregated to only one daughter at each division. The animals reach
adulthood and, despite abnormalities in the gonad lineage including
extra distal tip cells, produce sperm, oocytes, and, sometimes,
fertile eggs which develop abnormally. The Lin-23 product may be a
repressor of cell cycling.

Figure 1