Worm Breeder's Gazette 2(2): 35a
These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.
We have initiated single-cell biochemical studies of neurotransmitter metabolism in Ascaris des in order to determine which chemical transmitters are used by the identified somatic motorneurons of this nematode. Acetylcholine is a likely excitatory transmitter. We have studied the catalyzed formation of acetyl-[3H]-choline from [3H]-choline in transverse strips of hypodermal tissue containing the ventro-dorsal commissures of neurons with processes in the dorsal cord. Compared to hypodermal strips containing no neural tissue, elevated levels of ACh are synthesized by all strips containing the commissures of motorneurons which make excitatory neuromuscular synapses in the dorsal cord. The commissures of inhibitory neurons do not synthesize ACh.