Worm Breeder's Gazette 2(2): 24b

These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.

Informational Suppression in C. elegans

R.H. Waterston

In reversion studies of the null mutant E1214 of the paramyosin gene 
unc-15 a partial revertant has been isolated in which paramyosin is 
partially restored.  This is due to a second mutation, e1464, which 
maps in the cluster of LG III.  In addition, e1464, is able to 
suppress certain isolates and not others in several different 
complementation groups, some of which do not involve muscle.  These 
and other observations are consistent with the hypothesis that e1464 
results in informational suppression possibly of chain-terminating 
mutations, which is perhaps mediated by an altered tRNA species.