Worm Breeder's Gazette 11(5): 32

These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.

Comparison of the unc-104 Protein "Motor" Domain with Members of the Kinesin Family of Proteins

Anthony Otsuka, Lan Tang, Pratumtip Boontrakulpoontatwee, Yu Yong Zhang and Kristi Whiteaker

Figure 1

The unc-104 gene is capable of encoding a kinesin-related protein (
Otsuka et al., Neuron, in press).  Comparison of the presumed unc-104 
'motor' domain to the ATPase and microtubule-binding region of members 
of the kinesin family demonstrates the greatest sequence identity in 
the putative ATP-binding domain [GYN-TIFAYGQTGSGKTYTM-G] and in 
conserved elements of unknown function, some of which may be involved 
in microtubule-binding [GIIPR, VK-S(Y/F)-E(I/L)YNE, DLL, R-VA-T--N--
SSRSH-VF-I, SGKL-LVDLAGSE, GAEG-R--E--NINKSL--LG-VI-AL, HIPYR(D/E)SKLT-
LLQ-SLGG, N--ET-STL-(F/Y)A-RAK--(R/K)].  In the figure below, residues 
that are identical in 5 or more sequences are listed below the 
compilation and asterisks mark residues that are identical in all 
sequences.
[See Figure 1]