Worm Breeder's Gazette 11(4): 47

These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.

Nematode Protein Tyrosine Phosphatases

R. James Matthews, Robert H. Waterston and Matthew L. Thomas

Figure 1

Figure 2

Protein tyrosine phosphatases are an emerging group of proteins that 
may be important in controlling a variety of physiological processes 
in development and differentiation.  To date, five mammalian and two 
Drosophila protein tyrosine phosphatases have been described.  By use 
of PCR, we have isolated two cDNAs, nemPTP-1 and nemPTP-2, from a 
nematode library that have high similarity to protein tyrosine 
phosphatase catalytic domain sequences.  nemPTP-1 was mapped to YAC 
clones Y68C4, Y43E9 and Y50C5 which were derived from chromosome IV 
and locates nemPTP-1 near the unc-93 locus.  nemPTP-2 was mapped to 
YAC clones Y39E2, Y6G5, Y42G11 and Y54E6 which were derived from 
chromosome IV and locates nemPTP-2 near the col-2 locus.  The 
sequences and a comparison to a consensus protein tyrosine phosphatase 
sequence are shown in Fig.  1.  The cDNA clones are available to 
interested investigators.
[See Figures 1 & 2]

Figure 1

Figure 2