Worm Breeder's Gazette 11(4): 47
These abstracts should not be cited in bibliographies. Material contained herein should be treated as personal communication and should be cited as such only with the consent of the author.
Protein tyrosine phosphatases are an emerging group of proteins that may be important in controlling a variety of physiological processes in development and differentiation. To date, five mammalian and two Drosophila protein tyrosine phosphatases have been described. By use of PCR, we have isolated two cDNAs, nemPTP-1 and nemPTP-2, from a nematode library that have high similarity to protein tyrosine phosphatase catalytic domain sequences. nemPTP-1 was mapped to YAC clones Y68C4, Y43E9 and Y50C5 which were derived from chromosome IV and locates nemPTP-1 near the unc-93 locus. nemPTP-2 was mapped to YAC clones Y39E2, Y6G5, Y42G11 and Y54E6 which were derived from chromosome IV and locates nemPTP-2 near the col-2 locus. The sequences and a comparison to a consensus protein tyrosine phosphatase sequence are shown in Fig. 1. The cDNA clones are available to interested investigators. [See Figures 1 & 2]