CGC Bibliography Paper 5740

Tissue-specific expression, heat inducibility, and biological roles of two hsp16 genes in Caenorhabditis elegans.

Shim J, Im SH, Lee J

Medline:

12606046

Citation:

FEBS Letters 537: 139-145 2003

Type:

ARTICLE

Genes:

Abstract:

In this report we have examined two new heat shock protein (HSP16) proteins in the nematode Caenorhabditis elegans encoded by the open reading frames F08H9.3 and F08H9.4. The F08H9.3 and F08H9.4 genes are oriented in the same direction next to each other on the chromosome, not sharing any promoter region, unlike other hsp16 genes that share common promoters in pairs. The F08H9.3 and F08H9.4 proteins were expressed in a tissue-specific manner, unlike the other four HSP16 proteins. F08H9.3 was expressed in the pharynx, and F08H9.4 in the excretory canal and a few neuronal cells. While F08H9.3 was weakly induced by heat shock only in the same tissue as under the normal condition, F08H9.4 was newly induced in the intestine. RNA interference experiments showed that these two proteinsare required for survival under the heat shock condition.