CGC Bibliography Paper 5738

Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris.

Deepak M, Dipankar G, Prashanth D, Asha MK, Amit A, Venkataraman BV

Medline:

12587699

Citation:

Phytomedicine 9: 753-756 2002

Type:

ARTICLE

Genes:

Abstract:

Successive extracts of Tribulus terrestris prepared using petroleum ether, chloroform, 50% methanol and water were tested for anthelmintic activity in-vitro using the nematode Caenorhabditis elegans. The activity could be detected only in 50% methanol extract which on further bioactivity guided fractionation and chromatographic separation yielded a spirostanol type saponin, tribulosin and beta-sitosterol-D-glucoside. Both the compounds exhibited anthelmintic activity with ED50 of 76.25 and 82.50 microg/ml respectively.