CGC Bibliography Paper 5682

EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein.

Callebaut I, Mignotte V, Souchet M, Mornon JP

Medline:
12507493
Citation:
Biochemical and Biophysical Research Communications 300: 619-623 2003
Type:
ARTICLE
Genes:
ced-1
Abstract:
The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.