CGC Bibliography Paper 5682
EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein.
Callebaut I,
Mignotte V,
Souchet M,
Mornon JP
- Medline:
- 12507493
- Citation:
- Biochemical and Biophysical Research Communications 300: 619-623 2003
- Type:
- ARTICLE
- Genes:
- ced-1
- Abstract:
- The EMI domain, first named after its presence in proteins of the EMILIN family, was identified here in several metazoan proteins with various domain architectures, among which the mammalian NEU1/NG3 proteins and Caenorhabditis elegans CED-1, identified as a transmembrane receptor that mediates cell corpse engulfment. Functional data available for EMILIN proteins suggest that the EMI domain could be a protein-protein interaction module. Sequence profiles specific of the EMI family of domains led to identify the probable orthologs of the C. elegans CED-1 protein in mammals and insects, which were yet uncovered.