CGC Bibliography Paper 5679

One lucky XX male: isolation of the first Caenorhabditis elegans sex-determination mutants.

Hodgkin J

Medline:

12524326

Citation:

Genetics 162: 1501-1504 2002

Type:

REVIEW

Genes:

dpy-21 dpy-26 mab-3 tra-1 tra-2 tra-3

Abstract:

This article marks the 25th anniversary of a paper reporting the first sex-determination mutants to be found in the nematode Caenorhabditis elegans. The isolation of these mutants initiated an extensive analysis of nematode sex determination and dosage compensation, carried out by a number of laboratories over the subsequent decades. As a result, the process of sex determination is now one of the most thoroughly understood parts of C. elegans development, in both genetic and molecular terms. It has also proved to have interesting repercussions on the study of sex determination in other organisms.