CGC Bibliography Paper 5663
No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8.
Keaney M,
Gems D
- Medline:
- 12521609
- Citation:
- Free Radical Biology & Medicine 34: 277-282 2003
- Type:
- ARTICLE
- Genes:
- fog-2
- Abstract:
- The superoxide dismulase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions.