CGC Bibliography Paper 5663

No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8.

Keaney M, Gems D

Medline:
12521609
Citation:
Free Radical Biology & Medicine 34: 277-282 2003
Type:
ARTICLE
Genes:
fog-2
Abstract:
The superoxide dismulase mimetic EUK-8 has been reported to extend lifespan in the nematode Caenorhabditis elegans. However, in five trials administering EUK-8 in liquid culture with E. coli, and two trials using defined liquid medium, we observed no increase in C elegans lifespan. Instead we saw a dose-dependent reduction of lifespan and fertility. We conclude that extension of C. elegans lifespan by EUK-8 may only occur under very particular culture conditions.