CGC Bibliography Paper 5643

The evolution of signalling pathways in animal development.

Pires-daSilva A, Sommer RJ

Medline:
Citation:
Nature Reviews Genetics 4: 39-49 2003
Type:
REVIEW
Genes:
egl-1 fem-1 fem-2 fem-3 gsk-3 her-1 let-23 lin-31 mab-3 pry-1 sdc-1 sdc-2 sdc-3 tra-1 tra-2 tra-3 xol-1
Abstract:
Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell-cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-beta, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body