CGC Bibliography Paper 5643
The evolution of signalling pathways in animal development.
Pires-daSilva A,
Sommer RJ
- Medline:
-
- Citation:
- Nature Reviews Genetics 4: 39-49 2003
- Type:
- REVIEW
- Genes:
- egl-1 fem-1 fem-2 fem-3 gsk-3 her-1 let-23 lin-31 mab-3 pry-1 sdc-1 sdc-2 sdc-3 tra-1 tra-2 tra-3 xol-1
- Abstract:
- Despite the bewildering number of cell types and patterns found in the animal kingdom, only a few signalling pathways are required to generate them. Most cell-cell interactions during embryonic development involve the Hedgehog, Wnt, transforming growth factor-beta, receptor tyrosine kinase, Notch, JAK/STAT and nuclear hormone pathways. Looking at how these pathways evolved might provide insights into how a few signalling pathways can generate so much cellular and morphological diversity during the development of individual organisms and the evolution of animal body