CGC Bibliography Paper 5634

Protein histidine phosphatase: a novel enzyme with potency for neuronal signaling.

Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J

Medline:
12468887
Citation:
Journal of Cerebral Blood Flow & Metabolism 22: 1420-1424 2002
Type:
ARTICLE
Genes:
Abstract:
The importance of reversible phosphorylation for neuronal signaling and cell survival is well recognized. Knowledge in vertebrates, however, is so far limited to O-phosphates from serine, threonine, and tyrosine. The authors describe an enzyme acting on N-phosphates. It is the first protein histidine phosphatase identified in vertebrates. This histidine phosphatase is ubiquitously expressed in mammalian tissues including brain. Characterization and sequencing showed a yet unknown protein with no similarity to other phosphatases. In Caenorhabditis elegans, the homolog of this histidine phosphatase was exclusively expressed in neurons, suggesting a distinct role of reversible histidine phosphorylation in neuronal functions.