CGC Bibliography Paper 5627

Aquatic acute toxicity testing using the nematode Caenorhabditis elegans.

Ura K, Kai T, Sakata S, Iguchi T, Arizono K

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Citation:

Journal of Health Science 48: 583-586 2002

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ARTICLE

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Abstract:

To evaluate the toxicity of environmental chemicals to invertebrates, a static bioassay was developed in the laboratory using the Caenorhabditis elegans (C. elegans). First, reproducibility of this aquatic acute toxicity test system was confirmed. In order to estimate chemical toxicities in C. elegans, worms were subsequently exposed to eleven different xenobiotics. Mortality after 24hr was adopted as the endpoint of toxicity. We found that benzo[a]pyrene, nonylphenol, benzophenone, bisphenol A and cadmium chloride affected viability of C. elegans. These data suggest that C. elegans is a suitable toxicity test organism for environmental xenobiotic chemicals, and that lethality can be used as a testing endpoint.