CGC Bibliography Paper 5619

PKG and the neural basis for behavioral phenotypes.

Schafer WR

Medline:
12495614
Citation:
Neuron 36: 991-993 2002
Type:
REVIEW
Genes:
adp-1 egl-4 osm-9 tax-2
Abstract:
Cyclic GMP-dependent protein kinase (PKG) has been implicated in the regulation of diverse aspects of vertebrate and insect behavior, yet the mechanisms underlying these effects are poorly understood. In this issue of Neuron, Fujiwara et al. and L'Etoile et al. address the neural basis for PKG function in C. elegans and demonstrate the power of behavioral genetic analysis in simple systems in the elucidation of neuronal signaling mechanisms in vivo.