CGC Bibliography Paper 5575

Anterior-posterior polarity in C. elegans and Drosophila - PARallels and differences.

Pellettieri J, Seydoux G

Medline:

12471246

Citation:

Science 298: 1946-1950 2002

Type:

REVIEW

Genes:

mex-5 mex-6 par-1 par-2 par-3 par-4 par-5 par-6 pie-1 pkc-3

Abstract:

The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.