CGC Bibliography Paper 5571

The Caenorhabditis elegans sqv genes and functions of proteoglycans in development.

Bulik DA, Robbins PW

Medline:

12417407

Citation:

Biochimica et Biophysica Acta 1573: 247-257 2002

Type:

REVIEW

Genes:

dig-2 lag-2 let-23 let-60 lin-2 lin-3 lin-7 lin-12 lin-15 lin-39 pat-2 pat-3 rib-2 sem-5 sqv-3 sqv-7 sqv-8 unc-52

Abstract:

In the nematode Caenorhabditis elegans, the vulva is a simple tubular structure linking the gonads with the external cuticle. In this review we summarize knowledge of inter- and intracellular signaling during vulval development and of the genes required for vulval invagination. Mutants of one set of these genes, the sqv genes, have a normal number of vulval precursor cells (VPCs) with an unperturbed cell lineage but the invagination space, normally a tube, is either collapsed or absent. We review evidence that the sqv genes are involved in glycosaminoglycan synthesis and speculate on ways in which defective glycosaminoglycan formation might lead to