CGC Bibliography Paper 5536

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

Semenza GL

Medline:

Citation:

Cell 107: 1-3 2002

Type:

REVIEW

Genes:

egl-9 vhl-1

Abstract:

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O2 homeostasis in animals. A molecular basis for O2 regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.