CGC Bibliography Paper 5526
Protein oxidation during aging of the nematode Caenorhabditis elegans.
Ishii N,
Goto S,
Hartman PS
- Medline:
- 12374613
- Citation:
- Free Radial Biology & Medicine 33: 1021-1025 2002
- Type:
- REVIEW
- Genes:
- age-1 daf-2 daf-16 mev-1 old-1 old-2 sod-3
- Abstract:
- The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function.