CGC Bibliography Paper 5478

Genetic approaches to programmed cell death: achievements and questions.

Adam M, Levraud JP, Golstein P

Medline:

Citation:

M S-Medecine Sciences 18: 831-840 2002

Type:

REVIEW

Genes:

Abstract:

A useful approach to study molecular mechanisms of cell death is, classically, mutagenesis followed with identification of the altered gene. For caspase-dependent cell death, this has provided spectacular results in the nematode C. elegans more than in other organisms. Often different molecules have been identified as a function of the investigated organism. These differences reflect, sometimes the existence of pathways seemingly unique to certain species, sometimes selection biases linked to peculiarities of the organisms under investigation.