CGC Bibliography Paper 5455

Motor neuron specification in worms, flies and mice: conserved and "lost" mechanisms.

Thor S, Thomas JB

Medline:

12200161

Citation:

Current Opinion in Genetics & Development 12: 558-564 2002

Type:

REVIEW

Genes:

cnd-1 lin-11 pag-3 unc-3 unc-4 unc-30 unc-55 vab-7

Abstract:

Motor neuron differentiation has been studied intensively in both invertebrates and vertebrates in recent years. These studies have led to the identification of several key regulatory genes acting to generate motor neurons and to specify their subclass identities. By comparing findings from Caenorhabditis elegans, Drosophila and vertebrate model systems, it is apparent that both evolutionarily conserved and non-conserved mechanisms are used.