CGC Bibliography Paper 5453

The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.

Gruneberg U, Glotzer M, Gartner A, Nigg EA

Medline:

12213836

Citation:

Journal of Cell Biology 158: 901-914 2002

Type:

ARTICLE

Genes:

air-2 cdc-14 cyk-4 zen-4

Abstract:

As the primary microtubule-organizing center (MTOC) of the cell, the centrosome is a major structural determinant of the mitotic spindle. Like each chromosome, the centrosome must replicate once and only once per cell cycle in order to maintain the fidelity of nuclear division and the integrity of the genome. While the mechanisms that govern this process are not well understood and are sure to be complex, centrosome duplication can be described as involving three general steps. First, the centrosome splits to form two centrosomes, each with half the reproductive capacity of the original. Second, a replication step restores each new centrosome to full reproductive capacity. Third, the replicated centrosomes sever an remaining connections and move apart. In the past few years, several factors have been identified that regulate each of these steps. Among these factors is the ZYG-1 kinase of C. elegans, which functions during both mitotic and meiotic divisions (O'Connell et al., 2001).