CGC Bibliography Paper 5451

Control of cell polarity by noncanonical Wnt signaling in C. elegans.

Herman MA

Medline:

12137732

Citation:

Seminars in Cell & Developmental Biology 13: 233-241 2002

Type:

REVIEW

Genes:

apr-1 bar-1 dsh-2 egl-5 egl-20 end-1 hmp-2 lin-17 lin-39 lin-44 lit-1 mab-5 mig-1 mig-5 mig-14 mom-1 mom-2 mom-3 mom-4 mom-5 pop-1 pry-1 sgg-1 wrm-1

Abstract:

The three Caenorhabditis elegans beta-catenin each function in distinct processes: BAR-1 in canonical Wnt signaling that controls cell fates and cell migrations, HMP-2 in cell adhesion and WRM-1 in Wnt signaling pathways that function in conjunction with a mitogen-activated kinase (MAPK) pathway to control the orientations, or cell Polarities, of cells that undergo asymmetric cell divisions. In addition, WRM-1 does not interact with the canonical beta-catenin binding site in POP-1/Tcf. Thus, Wnt signaling through WRM-1 is noncanonical and, except for one division that might not include any of the three C. elegans beta-calenin, controls cell polarity in C. elegans.