CGC Bibliography Paper 5436

The Caenorhabditis elegans XPA homolog of human XPA.

Park HK, Yook JS, Koo HS, Choi IS, Ahn B

Medline:

12243352

Citation:

Molecules & Cells 14: 50-55 2002

Type:

ARTICLE

Genes:

Abstract:

The Xeroderma pigmentosum complementation group A (XPA) protein that is indispensable for nucleotide excision repair of DNA damage in eukaryotes participates in photoproduct recognition. A search of the current Caenorhabditis elegans database allowed us to identify a good candidate for the XPA protein homolog. We cloned a complete cDNA of C elegans XPA (Ce-XPA) by using RT-PCR. Northern blot analysis showed that the Ce-xpa gene is expressed in all of the stages, including embryos. Ce-XPA encodes a 241-amino acid protein that is homologous to all known eukaryotic XPA. Ce-XPA RNAi caused embryonic lethality and survival lethality to UV radiation. This result suggests that Ce-XPA is involved in the repair of