CGC Bibliography Paper 5430

Caenorhabditis elegans receptors related to mammalian vascular endothelial growth factor receptors are expressed in neural cells.

Popovici C, Isnardon D, Birnbaum D, Roubin R

Medline:

12161275

Citation:

Neuroscience Letters 329: 116-120 2002

Type:

ARTICLE

Genes:

ver-1 ver-2 ver-3 ver-4

Abstract:

Through a genomic survey of the Caenorhabditis elegans genome for genes encoding tyrosine kinase receptors (RTK) we identified a family of four RTKs which are structurally related to vascular enclothelial growth factor receptors (VEGFRs). We named this family the ver gene family (for Vascular Endothelial growth factor receptor Related). It was intriguing to find this type of RTK in an animal devoid of a vascular system. The common sites of expression of the ver genes are specialized cells of neural origin: ver-1 (T17A3.1) is expressed in the support (glial) cells of amphid and phasmid neurons, ver-2 (T17A3.8) in ADL, a pair of chemosensorial neurons, and ver-3 (F59F3.1) in the ALA neuron. In mammals, the VEGFRs are associated with angiogenesis and neurogenesis. We provide here the first observation that these molecules may be primarily and solely involved in neurogenesis in a living organism.