CGC Bibliography Paper 5405

Mechanisms of spindle positioning: focus on flies and

Gonczy P

Medline:

12185850

Citation:

Trends in Cell Biology 12: 332-339 2002

Type:

REVIEW

Genes:

ags-3.2 ags-3.3 goa-1 gpa-16 let-99 par-1 par-2 par-3 spn-4

Abstract:

Accurate spindle positioning is crucial for spatial control of cell division. During metazoan development, coordination between polarity cues and spindle position also ensures correct segregation of cell fate determinants. Converging evidence indicates that spindle positioning is achieved through interactions between cortical anchors and the plus ends of microtubules, generating pulling forces acting on spindle poles. This article discusses recent findings that indicate how this mechanism might be used for spindle positioning during Drosophila and Caenorhabditis elegans development.