CGC Bibliography Paper 5402

Post-transcriptional gene silencing by double-stranded RNA.

Hammond SM, Caudy AA, Hannon GJ

Medline:

Citation:

Nature Reviews Genetics 2: 110-119 2002

Type:

REVIEW

Genes:

ego-1 mut-2 mut-7 rde-1 rde-2 rde-3 rde-4

Abstract:

Imagine being able to knock out your favourite gene with only a day's work. Not just in one model system, but in virtually any organism: plants, flies, mice or cultured cells. This sort of experimental dream might one day become reality as we learn to harness the power of RNA interference, the process by which double-stranded RNA induces the silencing of homologous endogenous genes. How this phenomenon works is slowly becoming clear, and might help us to develop an effortless tool to probe gene function in cells and animals.