CGC Bibliography Paper 5399

RNAi (Nematodes: Caenorhabditis elegans).

Grishok A, Mello CC

Medline:
11931230
Citation:
Advances in Genetics 46: 339-360 2002
Type:
REVIEW
Genes:
ego-1 let-7 lin-4 mut-7 rde-1 rde-2 rde-4
Abstract:
RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.