CGC Bibliography Paper 5394

Long-lived mutants, the rate of aging, telomeres and the germline in Caenorhabditis elegans.

Benard C, Hekimi S

Medline:

Citation:

Mechanisms of Ageing & Development 123: 869-880 2002

Type:

REVIEW

Genes:

clk-1 clk-2 daf-2 daf-9 daf-12 daf-16 gro-1 isp-1 mrt-2 rad-5

Abstract:

Studying the phenomenon of aging is interesting for many reasons including because one would like to be able to extend the life span of people. However, we believe that the aging process instill so poorly understood that it remains unclear what exactly we will have to learn about it in order to understand it. Strehler, and others, have tried to ask questions about aging at several different levels at which biological systems can be studied (Strehler, 1985, 1995). Here, we will first discuss a number of nested viewpoints on aging, and then focus on some recent studies, particularly in Caenorhabditis elegans, in which several lines of investigation intersect: the study of long-lived mutants, the properties of the germline, and the biology of telomeres.