CGC Bibliography Paper 5379

Germ-line stem cells call the shots.

Tatar M

Medline:

Citation:

Trends in Ecology & Evolution 17: 297-298 2002

Type:

REVIEW

Genes:

daf-2 daf-12 daf-16 daz-1 fem-3 fez-1 fog-1 fog-2 fog-3 gld-1 glp-1 mes-1

Abstract:

In the nematode Caenorhabditis elegans, developmental biologists find that tissues derived from embryonic germ-line progenitor cells regulate reproductive costs. New work from the laboratory of Cynthia Kenyon demonstrates that signals that reduce adult survival are mediated by a small set of progenitor descendants, the germ-line stem cells, and by their interaction with components of the endocrine system. Caenorhabditis elegans is now providing a new way of understanding the mechanisms of tradeoffs between reproduction and ageing.