CGC Bibliography Paper 5376

Downstream targets of let-60 Ras in Caenorhabditis elegans.

Romagnolo B, Jiang M, Kiraly M, Breton C, Begley R, Wang J, Lund J, Kim SK

Medline:

12074557

Citation:

Developmental Biology 247: 127-136 2002

Type:

ARTICLE

Genes:

cat-2 ces-1 ces-2 let-23 let-60 sos-1

Abstract:

In Caenorhabditis elegans, let-60 Ras controls many cellular processes, such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out terminal effector functions leading to morphological change. We have used DNA microarrays to identify 708 genes that change expression in response to activated let-60 Ras.