CGC Bibliography Paper 5373

Genetics leads the way to the accomplices of presenilins.

Goutte C

Medline:

12110162

Citation:

Developmental Cell 3: 6-7 2002

Type:

REVIEW

Genes:

aph-1 aph-2 hop-1lin-12 pen-2 sel-12

Abstract:

Presenilins mediate they-secretase cleavage of Notch transmembrane receptors as well as the transmembrane P-amyloid precursor protein (PAPP), but they are not thought to accomplish this alone. Recent genetic screens in C. elegans, presented in this issue of Developmental Cell, identify two genes that are essential to gamma-secretase activity and may interact with presenilins.