CGC Bibliography Paper 5370
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
Kim DH,
Feinbaum R,
Alloing G,
Emerson FE,
Garsin DA,
Inoue H,
Tanaka-Hino M,
Hisamoto N,
Matsumoto K,
Tan MW,
Ausubel FM
- Medline:
- 12142542
- Citation:
- Science 297: 623-626 2002
- Type:
- ARTICLE
- Genes:
- esp-2 esp-8 glp-4 nsy-1 pmk-1 pmk-2 sek-1 unc-43
- Abstract:
- A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosa led to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse