CGC Bibliography Paper 5346

The gene expression and deficiency phenotypes of Cockayne syndrome B protein in Caenorhabditis elegans.

Lee MH, Ahn B, Choi IS, Koo HS

Medline:

12095617

Citation:

FEBS Letters 522: 47-51 2002

Type:

ARTICLE

Genes:

Abstract:

The Caenorhabditis elegans Cockayne syndrome B protein homologue is encoded by 10 exons of the predicted open reading frame F53H4.1. The gene is expressed in germ cells and all somatic cells of the embryonic to adult stage. Although the gene expression was ubiquitous, its expression level was relatively higher in dividing cells and cells that play fundamental roles in essential physiological functions such as feeding, sensation, and reproduction. RNA interference of the gene hypersensitized C. elegans to UV radiation, as observed in enhanced germ cell proliferation arrest and apoptosis, and increased embryonic lethality, suggesting its role in nucleotide excision repair.