CGC Bibliography Paper 5268

Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation.

Bui YK, Sternberg PW

Medline:

12006659

Citation:

Molecular Biology of the Cell 13: 1641-1651 2002

Type:

ARTICLE

Genes:

ipp-2 ipp-5 itr-1 let-23 lfe-1 lfe-2 lin-3 nlp-8

Abstract:

Ovulation in Caenorizabditis elegans requires inositol 1,4,5-triphosphate (IP3) signaling activated by the epidermal growth factor (EGF)-receptor homolog LET-23. We generated a deletion mutant of a type I 5-phosphatase, ipp-5, and found a novel ovulation phenotype whereby the spermatheca hyperextends to engulf two oocytes per ovulation cycle. The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP3 signaling in the adult spermatheca. ipp-5 acts downstream of let-23, and interacts with let-23-mediated IP3 signaling pathway genes. We infer that IPP-5 negatively regulates IP3 signaling to ensure proper spermathecal contraction.