CGC Bibliography Paper 5254
Rafting along the axon on Unc104 motors.
Scholey JM
- Medline:
-
- Citation:
- Developmental Cell 2: 515-516 2002
- Type:
- REVIEW
- Genes:
- unc-104
- Abstract:
- Neurotransmission depends upon the fast axonal transport of synaptic vesicle precursors by the monomeric kinesin Unc104, a motor whose mechanism of action is a topic of debate. New work suggests that the formation of lipid raft domains triggers the assembly of vesicle-bound Unc104 dimers and the concomitant activation of processive movement, facilitating efficient long-range vesicle