CGC Bibliography Paper 5228

CLK-1 protein has DNA binding activity specific to O-L region of mitochondrial DNA.

Gorbunova V, Seluanov A

Medline:

Citation:

FEBS Letters 516: 279-284 2002

Type:

ARTICLE

Genes:

clk-1

Abstract:

Mutations in the clk-1 gene of Caerzorhahditis elegans extend worm life span and slow down a variety of physiological processes. Here we report that C. elegans CLK-1 as well as its mouse homologue have DNA binding activity that is specific to the O-L region of mitochondrial DNA. DNA binding activity of CLK-1 is inhibited by ADP, and is altered by mutations that extend nematode life span. Our results suggest that, in addition to its enzymatic function in ubiquinone biosynthesis, CLK-1 is involved in the regulation of mtDNA replication or