CGC Bibliography Paper 5222
The gift of Gab.
Liu Y,
Rohrschneider LR
- Medline:
-
- Citation:
- FEBS Letters 515: 1-7 2002
- Type:
- REVIEW
- Genes:
- egl-15 let-60
- Abstract:
- Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.