CGC Bibliography Paper 5222

The gift of Gab.

Liu Y, Rohrschneider LR

Medline:
Citation:
FEBS Letters 515: 1-7 2002
Type:
REVIEW
Genes:
egl-15 let-60
Abstract:
Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.