CGC Bibliography Paper 5207

Model organisms as a guide to mammalian aging.

Tissenbaum HA, Guarente L

Medline:

11782310

Citation:

Developmental Cell 2: 9-19 2002

Type:

REVIEW

Genes:

age-1 akt-1 akt-2 clk-1 clk-2 clk-3 ctl-1 daf-2 daf-9 daf-12 daf-16 eat-2 gro-1 ins-1 ins-18 isp-1 mev-1 old-1 pdk-1 sod-1 sod-2 sod-3 unc-31 unc-64

Abstract:

Recent studies on aging in model systems such as yeast and roundworms have revealed conserved regulation of the process in response to nutrient availability and specific genes that appear to mediate this regulation. Here we review these findings with a focus on the nematode Caenorhabditis elegans and the budding yeast Saccharomyces cerevisiae and highlight general features of the regulation of aging that may have implications for mammals.