CGC Bibliography Paper 5201

Molecular mechanisms of developmental timing in C. elegans and Drosophila.

Thummel CS

Medline:

11703937

Citation:

Developmental Cell 1: 453-465 2001

Type:

REVIEW

Genes:

col-19 daf-9 daf-12 let-7 lin-4 lin-14 lin-28 lin-29 lin-41 lin-42 lrp-1 nhr-23 nhr-25

Abstract:

Characterization of the heterochronic genes has provided a strong foundation for understanding the molecular mechanisms of developmental timing in C. elegans. In apparent contrast, studies of developmental timing in Drosophila have demonstrated a central role for gene cascades triggered by the steroid hormone ecdysone. In this review, I survey the molecular mechanisms of developmental timing in C. elegans and Drosophila and outline how common regulatory pathways are beginning to emerge.