CGC Bibliography Paper 5195

The sterol-sensing domain: multiple families, a unique

Kuwabara PE, Labouesse M

Medline:

Citation:

Trends in Genetics 18: 193-201 2002

Type:

REVIEW

Genes:

che-14 lrp-1 npc-1 npc-2 ptc-1

Abstract:

The 'sterol-sensing domain' (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.