CGC Bibliography Paper 5165

Malignant worms: What cancer research can learn from C. elegans.

Saito RM, van den Heuvel S

Medline:

11901546

Citation:

Cancer Investigation 20: 264-275 2002

Type:

REVIEW

Genes:

air-1 air-2 akt-1 akt-2 apc-1 bar-1 cdk-4 ced-3 ced-4 ced-9 ces-1 ces-2 cki-1 cyd-1 cye-1 daf-4 daf-7 daf-18 egl-1 hmp-2 let-23 let-60 lin-12 lin-35 lin-45 mdf-1 mdf-2 pop-1 sli-1 sma-4 wrm-1

Abstract:

An important goal in cancer research is to identify and understand the molecular changes that transform normal cells into tumor cells. Ultimately, these insights should translate into opportunities for improved diagnosis and treatment. Over the past two decades, cancer researchers have identified an extensive series of genes that contribute to neoplastic transformation when genetically altered. A detailed understanding of how the normal and mutated gene products function in biological processes should expand the possibilities for therapeutic intervention. Revealing how a given gene acts amidst the tens of thousands of other genes in the cell remains a challenging task which usually requires a combination of genetic, molecular, biochemical, and cell biological approaches in a number of model systems. Over the past 25 years, genetic studies in the nematode Caenorhabditis elegans have made important contributions to our