CGC Bibliography Paper 3184

Innexins: a family of invertebrate gap-junction proteins.

Phelan P, Bacon JP, Davies JA, Stebbings LA, Todman M, Avery L, Baines RA, Barnes TM, Ford C, Hekimi S, Lee R, Shaw JE, Sta

Medline:

Citation:

Trends in Genetics 14: 348-349 1998

Type:

REVIEW

Genes:

eat-5 unc-7

Abstract:

In vertebrates, intercellular communication via gap junctions is mediated by the connexin family of molecules, which is made up of at least 13 members. These proteins, which have four transmembrane domains and intracellular C- and N-termini, oligomerize to form hemichannels. Oligomers in the adjacent membranes of two closely apposed cells 'dock' to form intercellular channels, through which ions and small molecules move.