CGC Bibliography Paper 3165

Understanding cell migration guidance: lessons from sex myoblast migration in C. elegans.

Chen EB, Stern MJ

Medline:

98392177

Citation:

Trends in Genetics 14: 322-327 1998

Type:

REVIEW

Genes:

dig-1 egl-15 egl-17 let-60 sem-5 unc-53 unc-71 unc-73

Abstract:

Studies of sex myoblast (SM) migration in the nematode Caenorhabditis elegans have shown that multiple guidance mechanisms cooperate to ensure the accurate and reproducible targeting of the SMs. Many issues arise in the analysis of SM migration, including the action of multiple guidance mechanisms, redundant sources of guidance information, the multiple uses of molecular components, and whether factors affect cell fate determination events or the guidance mechanisms themselves. These issues are common to many cell migration events and make the analysis of SM migration instructive to our general understanding of how cell migrations are controlled.