CGC Bibliography Paper 3140

Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression.

Montgomery MK, Fire A

Medline:

98341277

Citation:

Trends in Genetics 14: 255-258 1998

Type:

ARTICLE

Genes:

unc-22

Abstract:

Many fundamental natural processes have been uncovered not by preplanned scientific enquiry, but serendipitously by engineers and scientists who observed unexpected consequences of their manipulations. Biologists routinely use engineering to manipulate the expression of specific genes and, thus, understand (or benefit from) their function. Sometimes we wish to make a particular gene silent; at other times we want the genes to 'talk' more loudly.