CGC Bibliography Paper 3136

Essential cys-pro-cys motif of Caenorhabditis elegans copper transport ATPase.

Yoshimizu T, Omote H, Wakabayashi T, Sambongi Y, Futai M

Medline:

98357242

Citation:

Bioscience Biotechnology and Biochemistry 62: 1258-1260

Type:

ARTICLE

Genes:

cua-1

Abstract:

Caenorhabditis elegans putative copper ATPase (CUA-1) had been functionally expressed in a yeast Delta ccc2 mutant (copper ATPase gene disruptant). We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation could not rescue the yeast Delta ccc2 mutant, suggesting that the carboxyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is essential for copper transport.