CGC Bibliography Paper 3081

CHR3: A Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting.

Kostrouchova M, Krause M, Kostrouch Z, Rall JE

Medline:
98190051
Citation:
Development 125: 1617-1626 1998
Type:
ARTICLE
Genes:
lin-26 nhr-23
Abstract:
CHR3 is a Caenorhabditis elegans orphan nuclear hormone receptor highly homologous to Drosophila DHR3, an ecdysone-inducible gene product involved in metamorphosis, Related vertebrate factors include RORalpha/RZRalpha, RZRbeta and RevErb, Gel-shift studies show that CHR3 can bind the DRS-type hormone response sequence. CHR3 is a nuclear protein present in all blastomeres during early embryogenesis. During morphogenesis, both CHR3 protein and zygotically active reporter genes are detectable in epidermal cells and their precursors, Inhibition of the gene encoding CHR3 results in several larval defects associated with abnormal epidermal cell function, including molting and body size regulation, suggesting that CHR3 is an essential epidermal factor required for proper postembryonic development.