CGC Bibliography Paper 3075

Dosage compensation in flies and worms: The ups and downs of X-chromosome regulation.

Lucchesi JC

Medline:

98273328

Citation:

Current Opinion in Genetics & Development 8: 179-184 1998

Type:

REVIEW

Genes:

dpy-26 dpy-27 dpy-30 mix-1 sdc-2 sdc-3 xol-1

Abstract:

Dosage compensation ensures that individuals with a single X chromosome have the same amount of most X-linked gene products as those with two. In Drosophila, this equalization is achieved by a two-fold enhancement of the lever of transcription of the X in males (XY) relative to each X chromosome in females (XX). In Caenorhabditis, equalization of X-linked gene products between hermaphrodites (XX) and males (XO) is achieved by decreasing the activity of genes in the former. These two different solutions to the common problem of unequal dosage of X-linked genes in different sexes provide invaluable paradigms for the study of gene regulation at the level of