CGC Bibliography Paper 3072
Mutations that perturb vulval invagination in C. elegans.
Herman T,
Horvitz HR
- Medline:
- 98260731
- Citation:
- Cold Spring Harbor Symposia on Quantitative Biology 62: 353-360 1997
- Type:
- ARTICLE
- Genes:
- lin-12 sqv-1 sqv-2 sqv-3 sqv-4 sqv-5 sqv-6 sqv-7 sqv-8
- Abstract:
- During development, animals undergo dramatic changes in patterning as a result of the movement and shaping of epithelial cell layers. Sheets of epithelial cells fold, branch, spread, and detach from or fuse with one another to generate the three-dimensional topology of an embryo. One example of such a morphogenetic process is epithelial invagination, which generates tubular structures from flat epithelia. To invaginate, a flat sheet of epithelial cells bends and moves inward, its apical surface facing the concave side of the depression. During sea urchin and Drosophila gastrulation, an epithelium bends inward about a point to form the digestive tract. The result is a tube that is perpendicular to the original sheet. In contrast, vertebrate neurulation, which forms the spinal cord and brain, is initiated by the invagination of a sheet that bends along a line and results in a tube that is parallel to the original sheet....